{"limit":20,"offset":0,"total":2,"items":[{"id":"MONDO:0008039","category":"biolink:Disease","name":"tropical spastic paraparesis","description":"Tropical spastic paraparesis is a chronic systemic immune-mediated inflammatory myeloneuropathy, more frequently reported in women than in men, that usually presents in adulthood with slowly progressive spastic paraparesis of the lower limbs, bladder and bowel dysfunction, and sensory disturbances in the lower extremities (e.g. paresthesia and dysesthesia) and that is associated with a human T-cell lymphotropic virus type 1 (HTLV-1) infection.","xref":["DOID:321","EFO:0007527","GARD:0008208","ICD10CM:G04.1","ICD9:323.01","MEDGEN:18298","MESH:D015493","MedDRA:10044696","NANDO:1200206","OMIM:159580","Orphanet:289326","SCTID:714279000","UMLS:C0030481","icd11.foundation:1043229589"],"synonym":["HAM/TSP","HTLV-1 associated myelopathy/tropical spastic paraparesis","HTLV-1-associated myelopathy/tropical spastic paraparesis","Human T-cell leukaemia virus type 1 associated myelopathy/tropical spastic paraparesis","Human T-cell leukemia virus type 1 associated myelopathy/tropical spastic paraparesis","Human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis","Human T-lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis","TSP","ham","ham/TSP","myelopathy, HTLV-1-associated","tropical spastic paraparesis (formerly)","tropical spastic paraplegia"],"exact_synonym":["HAM/TSP","HTLV-1-associated myelopathy/tropical spastic paraparesis","Human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis","Human T-lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis","TSP","ham/TSP","tropical spastic paraplegia"],"broad_synonym":null,"narrow_synonym":null,"related_synonym":["HTLV-1 associated myelopathy/tropical spastic paraparesis","Human T-cell leukaemia virus type 1 associated myelopathy/tropical spastic paraparesis","Human T-cell leukemia virus type 1 associated myelopathy/tropical spastic paraparesis","ham","myelopathy, HTLV-1-associated","tropical spastic paraparesis (formerly)"],"deprecated":null,"in_taxon":null,"in_taxon_label":null,"iri":null,"same_as":null,"subsets":["gard_rare","nord_rare","ordo_disorder","orphanet_rare","otar","rare"],"file_source":"phenio_nodes","provided_by":"phenio_nodes","full_name":null,"symbol":null,"has_gene":null,"type":null,"has_attribute":null,"has_biological_sex":null,"synonyms":null,"namespace":"MONDO","has_phenotype":null,"has_phenotype_label":null,"has_phenotype_count":null,"has_phenotype_closure":null,"has_phenotype_closure_label":null,"has_descendant":null,"has_descendant_label":null,"has_descendant_count":null,"score":120.77139,"matched_field":"name","match_type":"exact","highlighting":{"name":["<em>tropical</em> <em>spastic</em> <em>paraparesis</em>"],"description":["<em>Tropical</em> <em>spastic</em> <em>paraparesis</em> is a chronic systemic immune-mediated inflammatory myeloneuropathy"],"synonym":["HTLV-1 associated myelopathy/<em>tropical</em> <em>spastic</em> <em>paraparesis</em>"]}},{"id":"MONDO:0017326","category":"biolink:Disease","name":"infective dermatitis associated with HTLV-1","description":"A rare and severe chronic disease characterized by recurrent chronic eczema (with erythematous, scaly and crusted lesions) mainly affecting seborrheic areas (e.g. scalp, forehead, eyelids, paranasal and periauricular skin, neck, axillae, and groin), a generalized fine papular rash, chronic nasal discharge with crusting of the anterior nares, and non-virulent Staphylococcus aureus or beta-hemolytic Streptococcus infections, thought to be a result of HTLV-1-induced immunosuppression. Lymphadenopathy, anemia, mild to moderate pruritus and increased incidence of other infections (e.g. crusted scabies) have also been reported in some patients. Patients may subsequently develop other HTLV-1 associated conditions such as adult T-cell leukemia/lymphoma and tropical spastic paraparesis.","xref":["GARD:0021135","MEDGEN:895843","NCIT:C129260","Orphanet:289347","UMLS:C4274291"],"synonym":["IDH","IDH Gene family","infective dermatitis associated with human T-lymphotropic virus type 1","infective dermatitis associated with human T-lymphotropic virus type I","isocitrate dehydrogenase Gene family"],"exact_synonym":["IDH","IDH Gene family","infective dermatitis associated with human T-lymphotropic virus type 1","infective dermatitis associated with human T-lymphotropic virus type I","isocitrate dehydrogenase Gene family"],"broad_synonym":null,"narrow_synonym":null,"related_synonym":null,"deprecated":null,"in_taxon":null,"in_taxon_label":null,"iri":null,"same_as":null,"subsets":["gard_rare","nord_rare","ordo_disorder","orphanet_rare","rare"],"file_source":"phenio_nodes","provided_by":"phenio_nodes","full_name":null,"symbol":null,"has_gene":null,"type":null,"has_attribute":null,"has_biological_sex":null,"synonyms":null,"namespace":"MONDO","has_phenotype":null,"has_phenotype_label":null,"has_phenotype_count":null,"has_phenotype_closure":null,"has_phenotype_closure_label":null,"has_descendant":null,"has_descendant_label":null,"has_descendant_count":null,"score":4.96955,"matched_field":null,"match_type":null,"highlighting":{"description":[" such as adult T-cell leukemia/lymphoma and <em>tropical</em> <em>spastic</em> <em>paraparesis</em>."]}}],"facet_fields":[{"label":"category","facet_values":[{"label":"biolink:Disease","count":2}]},{"label":"in_taxon_label","facet_values":[]}],"facet_queries":[],"scope":null}